Product Datasheet
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Anti-Mouse Interleukin-1 R1 (IL-1 R1)
Purified Low Endotoxin Functional Formulation
(Interleukin-1 R1)
Monoclonal Antibody
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Prod. No.:I-435
Clone:JAMA-147
Isotype:Armenian Hamster IgG
Conc.:1.0 mg/ml
Pkg. Size:50 µg, 500 µg, Custom
Description
Specificity:
Armenian Hamster Anti-Mouse IL-1 R1 (Clone JAMA-147) recognizes Mouse IL-1 R1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:
IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1α and IL-1ß exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1ß, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.

Known Species Cross Reactivity: Ms+
Host Species
Armenian Hamster
Formulation
This antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Storage and Stability
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
N, IP
Each investigator should determine their own optimal working dilution for specific applications.
Country of Origin
USA
Related Products
Armenian Hamster IgG Isotype Control-Low Endotoxin Functional Formulation (Leinco Prod. No.: I-140)
Anti-Mouse IL-1 R1, Type 1-Purified (Leinco Prod. No.: I-432)
Anti-Mouse IL-1 R1, Type 1-R-Phycoerythrin (Leinco Prod. No.: I-433)
Anti-Mouse IL-1 R1, Type 1-Biotin (Leinco Prod. No.: I-434)
Anti-Mouse IL-1 R1 (Leinco Prod. No.: I-704)
PN:
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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