APRIL (Extracellular Domain-1) Blocking Peptide
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Antibody DetailsProduct DetailsReactive Species Human Product Concentration 0.2 mg/ml Amino Acid Location This peptide sequence is located at amino acids 67 to 79 of Human APRIL protein. Formulation This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Storage and Handling Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient Amino Acid Sequence 13 amino acids near the extracellular domain of human APRIL. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Background A proliferation-inducing ligand (APRIL) is a TNF-like cytokine that stimulates tumor cell growth.1 It is of low abundance in normal tissues.2 APRIL acts as a proliferative factor in megakaryocytopoiesis, a developmental hematopoietic process responsible for progenitor cell differentiation to megakaryoblasts and megakaryocytes, leading to platelet formation.3 APRIL may be implicated in the regulation of tumor cell growth.2 Antigen DetailsReferences & Citations1. Sarah G. Hymowitz et al. (2004) J Mol Biol. 343: 283
2. (1998) Jürg Tschopp
3. Ruggero De Maria et al. (2004) Blood 104: 3169
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
