Angiotensin-Converting Enzyme 2 (Intermediate Domain - 2) Blocking Peptide
(ACEH)
Blocking Peptide
| Prod. No.: | A296 |
| Conc.: | 0.2 mg/ml |
| Pkg. Size: | 50 µg |
| Storage: | -20°C Detailed storage instructions below. |
Description
Background:
Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9].1 ,or the conversion of angiotensin II to angiotensin 1-7.2 ACE 2 has direct effects on cardiac function2, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.3 ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH).4 ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).5
Amino Acid Location
15 amino acids near the center of human ACE2.
Formulation
This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.
Storage and Stability
Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
References
1. Acton S et al. (2000) Circ Res. 87: E1
2. Gamliel-Lazarovich A et al. (2007) Cardiovasc Res. 73: 463
3. Nabel EG et al. (2000) N Engl J Med. 347: 1795
4. Raizada MK et al. (2009) Am J Respir Crit Care Med.
5. Yuan Y et al. (2009) Tohoku J Exp Med. 217: 123
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
