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Anti-Human CD11a (CD11a)
Purified Low Endotoxin Functional Formulation
(LFA-1α Subunit Integrin αMβ2)
Monoclonal Antibody
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Prod. No.:C373
Clone:38
Isotype:Mouse IgG2a
Conc.:1.0 - 5.0 mg/ml
Pkg. Size:100 µg, 500 µg, 1 mg, Custom
Storage:Sterile 2-8°C Detailed storage instructions below.
Description
Specificity:
Mouse Anti-Human CD11a (Clone 38) recognizes Human CD11a. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Anti-Human CD11a (Anti-LFA-1a) recognizes the (Mr 175 kDa) a chain of the leukocyte function associated antigen-1 (LFA-1). The leukocyte integrin LFA-1 is a member of a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions.1 LFA-1α binds to domain 1 of an intercellular adhesion molecule (ICAM) on target tissues.

Antigen Distribution:
The CD11a antigen is present on most leukocytes and plays a vital role in cellular immune responses which require adhesion. Lymphocyte activation via the T-cell antigen receptor (TCR) up-regulates LFA-1 function. The absence of LFA-1α or ß may induce the disease state known as leukocyte adhesion deficiency (LAD). Tumor cells which do not express LFA-1 may have avoided cellular immune-responses such as those carried out by natural killer cells (NK).

Background:
Anti-CD11a may be used to study a variety of biological phenomena related to the function of cell adhesion molecules. This antibody may be used to study transplantation rejections and to assist in characterizing lymphomas and leukemias.

Host Species
Mouse
Formulation
This antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Storage and Stability
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
FC
Each investigator should determine their own optimal working dilution for specific applications.


Country of Origin
USA
References
1. Dransfield, I. et al. (1989) The EMBO Journal 8:3759
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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