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Anti-Human Thyroid Stimulating Hormone Beta (TSH-β)
Horseradish Peroxidase (HRPO)
(HCG, GPH, GPHA1, CG, Thyrotropin)
Monoclonal Antibody
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Size


Prod. No.:H106
Clone:195
Isotype:Mouse IgG
Conc.:0.5 mg/ml
Pkg. Size:1.0 ml
Description
Specificity:
Mouse Anti-Human Thyroid Stimulating Hormone Beta (TSH-β) (Clone 195) recognizes Human Thyroid Stimulating Hormone Beta . This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:
Thyroid-stimulating hormone (TSH), also known as thyrotropin, is a glycoprotein hormone1 that regulates the endocrine function of the thyroid gland.2 The most important controller of TSH secretion is thyroid-releasing hormone. Thyroid-releasing hormone is secreted by hypothalamic neurons into hypothalamic-hypophyseal portal blood, finds its receptors on thyrotrophs in the anterior pituitary and stimulates secretion of TSH.1 Independent of age, thyroid cancer incidence correlates with higher TSH. Higher TSH is associated with extrathyroidal extension of disease.3

Reporter Molecule:
Horseradish Peroxidase (HRPO) is an enzyme purified from horseradish root with a molecular weight of approximately 44 kDa.

Affinity:
3 X 1010
Host Species
Mouse
Immunogen
Purified Recombinant Human TSH-β (>98%)
Formulation
This horseradish peroxidase conjugate is supplied in a specially formulated stabilization diluent.(Leinco Prod. No.: S509)
Cross Reactivity
Paired with Leinco Prod. No. T100, Clone No. 154: TSH 100%, BhCG < 1%, ihCG < 1%, LH <1%, FSH < 1%. Paired with Leinco Prod. No. T101, Clone No. 183: TSH 100%, BhCG < 1%, ihCG < 1%, LH 1%, FSH < 1%.
Storage and Stability
Stable for at least one year when stored at 2°C - 8°C. Do not freeze.
Reported Applications
ELISA Det
Each investigator should determine their own optimal working dilution for specific applications.


Country of Origin
USA
References
1. (1998) Bowen A
2. McPherson et al. (2000) Placenta 24: 941
3. Wenger, R H et al. (2003) Wildmann's Clinical Interpretation of Laboratory Tests
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Anti-Human Thyroid Stimulating Hormone Beta Horseradish Peroxidase (Leinco Prod. No.: H113)
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Anti-Human Thyroid Stimulating Hormone Beta Purified (Leinco Prod. No.: T101)
Anti-Human Thyroid Stimulating Hormone Beta Purified (Leinco Prod. No.: T102)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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