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Anti-Human Chorionic Gonadotropin (HCG)

Horseradish Peroxidase (HRPO)

(CGB, CGB3, hCGB, MGC119822)

Monoclonal Antibody

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Size

1.0 ml ( $178.00 )

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Prod. No.:	H102
Clone:	150
Isotype:	Mouse IgG
Conc.:	0.5 mg/ml
Pkg. Size:	1.0 ml

Description

Specificity:

Mouse Anti-Human Chorionic Gonadotropin (HCG) (Clone 150) recognizes Human Chorionic Gonadotropin. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced in pregnancy that is made by the embryo soon after conception and later by the syncytiotrophoblast (part of the placenta). Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans. hCG may have additional functions; for instance, it is thought that hCG affects the immune tolerance of the pregnancy. Early pregnancy testing, in general, is based on the detection or measurement of hCG. Because hCG is produced also by some kinds of tumor, hCG is an important tumor marker, but it is not known whether this production is a contributing cause or an effect of tumorigenesis.

Reporter Molecule:

Horseradish Peroxidase (HRPO) is an enzyme purified from horseradish root with a molecular weight of approximately 44 kDa.

Affinity:

1 X 10¹⁰

Host Species

Mouse

Immunogen

Purified Recombinant Human HCG (>98%)

Formulation

This horseradish peroxidase conjugate is supplied in a specially formulated stabilization diluent.(Leinco Prod. No.: S509)

Cross Reactivity

hCG Test Paired with Leinco Prod. No. C103 Clone No. 152: ihCG 111%, BhCG 100%, LH < 3%, FSH < 1%, TSH < 1%. LH Test Paired with Leinco Prod. No. L100 Clone No. 196: LH 100%, BhCG < 1%, FSH < 1%, ihCG 78%, TSH < 1%. Paired with Leinco Prod. No. L101 Clone No. 199: LH 100%, BhCG < 1%, FSH < 1%, ihCG 3%, TSH < 1%.

Storage and Stability

Stable for at least one year when stored at 2°C - 8°C. Do not freeze.

Reported Applications

ELISA Det,

ELISA Sandwich Assay: 1234

Each investigator should determine their own optimal working dilution for specific applications.

Country of Origin

USA

References

1. (2007 Feb. 23) Int. J. Gynaecol. Obstet.
2. (2007 Feb. 15) Fertil. Steril.
3. (2007 Feb. 9) Fertil. Steril.
4. (2007 Feb. 9) Fertil. Steril.
5. (2006 Mar.) Taiwan J. Obstet. Gynecol. 45(1):48
6. (2007 Jan. 26) Fertil. Steril.