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Anti-Human Rhodopsin
Purified
(RHO, MGC138309, MGC138311, OPN2, RP4, Visual Purple, Opsin 2)
Monoclonal Antibody
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Size


Prod. No.:R127
Clone:RET-P1
Isotype:Mouse IgG1
Conc.:0.5 mg/ml
Pkg. Size:0.125 mg
Storage:2-8°C Detailed storage instructions below.
Description
Specificity:
Mouse Anti-Human Rhodopsin (Clone RET-P1) recognizes a (Mr 39 kD) glycoprotein which is a visual pigment in mammals, birds, amphibians and reptiles.1,2,3

Antigen Distribution:
The Rhodopsin antigen is present on the photoreceptor cells in the retina. The antibody RET-P1 specifically labels the axons and synaptic pedicles of the rods being labelled.1,2,3

Background:
Rhodopsin, also known as visual purple, is expressed in metazoan photoreceptor cells. It is a pigment of the retina that is responsible for both the formation of the photoreceptor cells and the first events in the perception of light. Rhodopsins belong to the class of G-protein coupled receptors. Rhodopsin is extremely sensitive to light, and enables night-vision. Exposed to white light, the pigment immediately bleaches, and it takes about 30 minutes to regenerate fully in humans.

Known Species Cross Reactivity: Ms+, Hu+, Rt+, Rb+, Bov+, Ar.Hms+, Shp+, Mky+, GP+, CK+, Bab+, Dog+, Bird, Reptile
Host Species
Mouse
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Stability
This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), IP, WB
Each investigator should determine their own optimal working dilution for specific applications.
Country of Origin
USA
References
1. Barnstable, C. J. et al. (1980) Nature 286:231
2. Hicks, D. et al. (1987) J. Histochem. Cytochem. 35:1317
3. Treisman, J. E. et al. (1988) Molec. Cell. Biol. 8:1570
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Human Whole Eye Tissue Lysate (Leinco Prod. No.: H1422)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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