Specificity:

Rabbit Anti-Human ADAM10 recognizes an epitope near the C-terminus of Human ADAM10. This polyclonal antibody was purified using affinity chromatography.

Background:

Proinflammatory cytokine tumor necrosis factor-α (TNF-α) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-α, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-α, notch and its ligand delta.^1,2,3 The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively.^1,2,4 ADAM10 mRNA is expressed in a variety of human and bovine tissues.^1,4

Known Species Cross Reactivity: Hu+