Anti-Human Clusterin

Anti-Human Clusterin

Product No.: C1298

[product_table name="All Top" skus="C1298"]

- -
- -
Target
Clusterin
Product Type
Polyclonal Antibody
Alternate Names
Complement Lysis Inhibitor, CLI, Apolipoprotein J, ApoJ
Applications
IHC FF
,
IHC FFPE
,
WB

- -
- -
Product Size
- -
- -

Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Clusterin recognizes Human Clusterin. This polyclonal antibody was purified using affinity chromatography.
Background
Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer’s b-amyloid peptide.1 Clusterin expression is increased in Alzheimer’s disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites2 and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression.3 Clusterin exists in at least two distinct isoforms.

Antigen Details

PubMed
NCBI Gene Bank ID

References & Citations

1. Calero, M. et al. (2005) Biochem. 38:273 2. Martin-Rehrmann, M. D. et al. (2005) Neurotox. Res. 7:231 3. Trougakos, I. P. et al. (2002) Int. J. Biochem. Cell Biol. 34:1430 4. Martinon, F. et al. (2005) TRENDS Imm. 26:447
IHC FF
IHC FFPE
General Western Blot Protocol
- -
- -
Prod No.
Description
C1298
Products are for research use only. Not for use in diagnostic or therapeutic procedures.