Specificity:

Rabbit Anti-Human DDX3 recognizes an epitope in the intermediate domain of Human, Mouse and Rat DDX3. This polyclonal antibody was purified using affinity chromatography.

Background:

DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases.^1,2 DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome.³ DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation.⁴ It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.

Known Species Cross Reactivity: Ms+, Hu+, Rt+