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Rabbit Anti-Human Glial Cell Line-Derived Neurotropic Factor soluble Receptor Alpha 2 (GFRα-2)
Purified No Carrier Protein
(GDNFRB, NRTNR-Alpha, NTNRA, RETL2, TRNR2)
Polyclonal Antibody
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Prod. No.:G577
Host:Rabbit
Conc.:0.5 mg/ml
Pkg. Size:0.1 mg, 0.5 mg, 1 mg
Storage:2-8°C Detailed storage instructions below.
Description
Specificity:
Rabbit Anti-Human GFRα-2 recognizes an epitope in the intermediate domain of Human, Mouse and Rat GFRα-2. This polyclonal antibody was purified using affinity chromatography.

Background:
Glial cell line-derived neurotrophic factor family receptor alpha-2, also known as GFRA2, is the cognate co-receptor for the neurotrophic factor neurturin that is selectively expressed by isolectin B(4) (IB 4)-binding nociceptive sensory neurons.1 GFRA2 is required for the development of the myenteric nerve plexus and is an excellent candidate gene for Hirschsprung disease (HSCR).2 GFRalpha2 signaling is also needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.3

Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
GFRα-2 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: G624)
Blocking Peptide
GFRα-2 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: G624)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Each investigator should determine their own optimal working dilution for specific applications.


Country of Origin
USA
References
1. Lewin GR et al. (2002) J Physiol. 545: 43
2. Mulligan Lois M et al. (2001) Human Genetics 108: 409
3. Herzig KH et al. (2005) Diabetes 54: 1324
Related Products
GFRα-2 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: G624)
Recombinant Mouse GFRα-2 (Leinco Prod. No.: G646)
Recombinant Human GFRα-2 (Leinco Prod. No.: G649)
Anti-Mouse GFRα-2 (Antigen Aff. Pur.) (Leinco Prod. No.: G660)
Anti-Human GFRα-2 (Antigen Aff. Pur.) (Leinco Prod. No.: G683)
Anti-Mouse GFRα-2-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: G689)
Anti-Human GFRα2-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: G693)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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