Anti-Human GFRα-2 (Intermediate Domain)
Anti-Human GFRα-2 (Intermediate Domain)
Product No.: G577
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Target Glial Cell Line-Derived Neurotropic Factor soluble Receptor Alpha 2 Product Type Polyclonal Antibody Alternate Names GDNFRB, NRTNR-Alpha, NTNRA, RETL2, TRNR2 Applications IHC FFPE , WB |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:G624 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830236 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Human GFRα-2 recognizes an epitope in the intermediate domain of Human, Mouse and Rat GFRα-2. This polyclonal antibody was purified using affinity chromatography. Background Glial cell line-derived neurotrophic factor family receptor alpha-2, also known as GFRA2, is the cognate co-receptor for the neurotrophic factor neurturin that is selectively expressed by isolectin B(4) (IB 4)-binding nociceptive sensory neurons.1 GFRA2 is required for the development of the myenteric nerve plexus and is an excellent candidate gene for Hirschsprung disease (HSCR).2 GFRalpha2 signaling is also needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.3 Antigen DetailsNCBI Gene Bank ID UniProt.org References & Citations1. Lewin GR et al. (2002) J Physiol. 545: 43
2. Mulligan Lois M et al. (2001) Human Genetics 108: 409
3. Herzig KH et al. (2005) Diabetes 54: 1324
Technical ProtocolsIHC FFPE  |
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Prod No. | Description |
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G577 | |
G624 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
