Specificity:

Rabbit Anti-Human I-Kappa-B Kinase Gamma (IKKγ) recognizes an epitope near the N-terminus of Human, Mouse and Rat IKKγ. This polyclonal antibody was purified using affinity chromatography.

Background:

Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-κB activity. The IkB kinase (IKKα and IKKβ) phosphorylates IkB and mediates NF-κB activation. A novel molecule in the IKK complex was recently identified and termed IKKγ/NEMO/FIP3/IKKAP1.^1-4 IKKg interacts with IKKβ and is required for the activation of IKK complex and NF-κB by LPS, PMA, TNF, and IL-1 stimulation.^1-4 FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κB activation.³

Known Species Cross Reactivity: Ms+, Hu+, Rt+