Specificity:

Rabbit Anti-Human Kelch-Like 1 Protein (KLHL1) recognizes an epitope near the N'terminus of human and rat KLHL1. This polyclonal antibody was purified using affinity chromatography.

Background:

The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues.^1,2 The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins.³ Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.¹

Known Species Cross Reactivity: Hu+, Rt+