Anti-Human PEN2 (NT)

Anti-Human PEN2 (NT)

Product No.: P206

[product_table name="All Top" skus="P206"]

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Target
PEN2
Product Type
Polyclonal Antibody
Alternate Names
Presenilin Enhancer Protein 2, Gamma-Secretase Subunit PEN-2
Applications
WB

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Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:P216
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human PEN2 recognizes an epitope near the N-terminus of human, mouse and rat PEN2. This polyclonal antibody was purified using affinity chromatography.
Background
PEN2, in addition to presenilin, nicastrin, and APH-1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease(1,2 for review). Like the tumor necrosis factor-α-converting enzyme (TACE) and the β-site cleavage enzyme (BACE) protease families, γ-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the α and γ cleavage site) or the toxic A/β amyloid peptide (from the β and γ cleavage site)(3). It is thought that accumulation of the Aβ peptide is the precursor to Alzheimer’s disease(4).

Antigen Details

PubMed
NCBI Gene Bank ID

References & Citations

1. Weihofen, A. et al. (2003) Trends Cell Biol. 13:71 2. Periz, G. et al. (2004) J. Neurosci. Res. 77:309 3. Selkoe, D. J. (1998) Trends Cell Biol. 8:447 4. Selkoe, S. J. (1999) Nature 399:A23
General Western Blot Protocol
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Prod No.
Description
P205
P206
Products are for research use only. Not for use in diagnostic or therapeutic procedures.