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Rabbit Anti-Human SARS Spike (SARS Spike)
Purified No Carrier Protein
Polyclonal Antibody
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Prod. No.:S544
Host:Rabbit
Conc.:0.5 mg/ml
Pkg. Size:0.1 mg, 0.5 mg, 1 mg
Storage:2-8°C Detailed storage instructions below.
Description
Specificity:
Rabbit Anti-Severe Acute Respiratory Syndrome Spike (SARS Spike) recognizes an epitope near the N-terminus of SARS Spike. This polyclonal antibody was purified using affinity chromatography.

Background:
A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome).1-2 Coronaviruses are a major cause of upper respiratory diseases in humans.3 The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.4

Known Species Cross Reactivity: Virus
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
Indirect ELISA
Each investigator should determine their own optimal working dilution for specific applications.


Country of Origin
USA
References
1. Marra, M. A. et al. (2003) Science 300:1399
2. Rota, P. A. et al. (2003) Science 300:1394
3. Navas-Nartin, S. R. et al. (2004) J. Neurovirol. 10:75
4. Li, W. et al. (2003) Nature 426:450
Related Products
Anti-Severe Acute Respiratory Syndrome Spike (CT) (SARS Spike) (Leinco Prod. No.: S540)
Anti-Severe Acute Respiratory Syndrome Spike (Intermediate Domain 1) (SARS Spike) (Leinco Prod. No.: S541)
Anti-Severe Acute Respiratory Syndrome Spike (Intermediate Domain 2) (SARS Spike) (Leinco Prod. No.: S542)
Anti-Severe Acute Respiratory Syndrome Spike (Intermediate Domain 3) (SARS Spike) (Leinco Prod. No.: S543)
Severe Acute Respiratory Syndrome Spike (CT) Blocking Peptide (Leinco Prod. No.: S549)
Severe Acute Respiratory Syndrome Spike (Intermediate Domain - 1) Blocking Peptide (Leinco Prod. No.: S550)
Severe Acute Respiratory Syndrome Spike (Intermediate Domain - 2) Blocking Peptide (Leinco Prod. No.: S551)
Severe Acute Respiratory Syndrome Spike (Intermediate Domain - 3) Blocking Peptide (Leinco Prod. No.: S552)
Severe Acute Respiratory Syndrome Spike (NT) Blocking Peptide (Leinco Prod. No.: S553)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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