Recombinant Adrenocorticotropic Hormone (ACTH)
(Tetracosactide, Corticotrophin)
| Prod. No.: | A331 |
| Source | Synthetic |
| Pkg. Size: | 50 mg, 2 mg, 10 mg |
| Storage: | -20°C Detailed storage instructions below. |
Description
Background:
Adrenocorticotropic hormone (ACTH or corticotrophin) is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is also produced by cells of immune system (T cells, B cells and macrophages). It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress. Its principal effects are increased production of androgens and cortisol from the adrenal cortex. ACTH may be considered as a useful adjunctive therapy in patients with intractable generalized seizures.1
Source
Synthetic
State of Matter
Purity
>98% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<0.125 EU/µg
Amino Acid Sequence
Its molecular weight is 4541.3 having an amino acid sequence of H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH.
Country of Origin
USA
References
1. Arya R et al. (2009) Indian J Pediatr. 76: 91
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
