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Recombinant Human Activin Receptor-Like Kinase 1 (ALK-1)
Purified No Carrier Protein
(ACVRL1, ACVRLK1, HHT, HHT2, ORW2, SKR3, TSR-I)
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Prod. No.:A343
SourceNSO Cells
Pkg. Size:100 µg, 1 mg
Storage:-20°C to -70°C Detailed storage instructions below.
Description
Background:
Activin A receptor type II-like 1, also known as ACVRL1, is a human gene. ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as "activin receptor-like kinase 1", or "ALK1". This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 suggesting a critical role for ALK-1 in the control of blood vessel development or repair.

Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular regions.

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human ALK-1 is Mr 37.3 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 50-55 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>90% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
dpvkpsrgp lvtctcesph ckgptcrgaw ctvvlvreeg rhpqehrgcg nlhrelcrgr ptefvnhycc dshlcnhnvs lvleatqpps eqpgtdgqie gridpkscdk thtcppcpap ellggpsvfl fppkpkdtlm isrtpevtcv vvdvshedpe vkfnwyvdgv evhnaktkpr eeqynstyrv vsvltvlhqd wlngkeykck vsnkalpapi ektiskakgq prepqvytlp psrdeltknq vsltclvkgf ypsdiavewe sngqpennyk ttppvldsdg sfflyskltv dksrwqqgnv fscsvmheal hnhytqksls lspgk



Country of Origin
USA
Related Products
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Anti-Mouse -ALK-1Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: A404)
Anti-Human ALK-1 (Leinco Prod. No.: A378)
Anti-Mouse ALK-1 (Antigen Aff. Pur.) (Leinco Prod. No.: A390)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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