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Recombinant Human Chemokine (C-C Motif) Ligand 16 (CCL16)
Purified No Carrier Protein
(LEC, NCC-4, HCC-4, LMC, LCC-1, MTN-1, IL-10-Inducible Chemokine, SCYA16, SCYL4, CKb12)
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Prod. No.:L124
SourceE. coli
Pkg. Size:25 µg, 1 mg
Storage:-20°C to -70°C Detailed storage instructions below.
Description
Background:
Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus, and spleen and is chemoattractive for monocytes and lymphocytes.1 Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. CCL16 is a potent maturation factor for monocyte-derived DCs (MoDCs) through differential use of its four receptors and an indirect regulator of Th cell differentiation.2 CCL16 play a role in hepatic vascular formation during development and in angiogenesis associated to hepatic diseases.3

Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human CCL16 is Mr 11 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
qpkvpew vntpstcclk yyekvlprrl vvgyrkalnc hlpaiifvtk rnrevctnpn ddwvqeyikd pnlpllptrn lstvkiitak ngqpqllnsq



Country of Origin
USA
References
1. Youn et al.(1998) Biochem. Biophys. Res. Commun. 247: 217
2. Giovarelli M. et al.(2006) J. Immunol. 177: 6143
3. Bussolino F. et al.(2004) Blood 103: 40
Related Products
Anti-Human CCL16 (Antigen Aff. Pur.) (Leinco Prod. No.: L125)
Anti-Human CCL16-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: L139)
Anti-Human CCL16 (Antigen Aff. Pur.) (Leinco Prod. No.: C1481)
Anti-Human CCL16 (Leinco Prod. No.: L147)
Recombinant Human CCL16 (Leinco Prod. No.: H1478)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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