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Recombinant Mouse Fractalkine (FKN)
Purified No Carrier Protein
(CX3CL1, NTN, ABCD-3, C3Xkine, CXC3, CXC3C, NTT, SCYD1, Neurotactin )
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Prod. No.:F1035
SourceE. coli
Pkg. Size:25 µg, 1 mg
Storage:-20°C to -70°C Detailed storage instructions below.
Description
Background:
Fractalkine (FKN) is a transmembrane mucin-chemokine hybrid molecule expressed on activated endothelium1 that mediates attachment and firm adhesion of T cells, monocytes and NK cells.2 FKN plays an important proinflammatory role in rheumatoid arthritis (RA) pathogenesis as characterized by induction of synovial angiogenesis, chemotaxis, activation of monocytes and T cells as well as the stimulation of proliferation and synthesis of matrix degrading enzymes (matrix metalloproteinases, MMP) in synovial fibroblasts. Fractalkine thus may represent a novel target molecule for therapeutic intervention in RA.3 FKN is also an essential biomarker for predicting the prognosis of patients with colorectal cancer (CRC).4

Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Mouse Fractalkine is Mr 9.5 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
lpgqhlgmt kceimcgkmt sripvallir yqlnqescgk raivlettqh rrfcadpkek wvqdamkhld hqaaaltkng gkfek



Country of Origin
USA
References
1. Patel DD et al. (1998) J Exp Med. 188: 1413
2. Hwang ST et al. (1999) Eur J Immunol. 29: 2551
3. Muller GA et al. (2008) Z Rheumatol. 67: 424
4. Mori M et al. (2005) Int J Oncol. 26: 41
Related Products
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Recombinant Human Fractalkine (CX3CL1) (Leinco Prod. No.: F1030)
Recombinant Mouse Fractalkine (Leinco Prod. No.: F1036)
Recombinant Rat Fractalkine (Chemokine Domain, aa 25-100) (Leinco Prod. No.: F1038)
Recombinant Mouse Fractalkine (Fragmented) (Leinco Prod. No.: F1040)
Anti-Human Fractalkine (Leinco Prod. No.: C1405)
Anti-Human Fractalkine (Leinco Prod. No.: C1406)
Anti-Rat Fractalkine (Leinco Prod. No.: C1438)
Anti-Mouse Fractalkine (Leinco Prod. No.: C1442)
Anti-Rat Fractalkine (Antigen Aff. Pur.) (Leinco Prod. No.: C1467)
Anti-Human Fractalkine-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: C1492)
Anti-Rat Fractalkine-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: C1512)
Anti-Human Fractalkine-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: F136)
Anti-Mouse Fractalkine (Antigen Aff. Pur.) (Leinco Prod. No.: F1069)
Recombinant Human Fractalkine (CX3CL1) (Leinco Prod. No.: F116)
Recombinant Rat Fractalkine (Leinco Prod. No.: F1115)
Anti-Mouse Fractalkine-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: F1098)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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