Anti-Rat Leptin-Biotin (Antigen Aff. Pur.)

Product Datasheet

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Goat Anti-Rat Leptin

Biotin

(Obesity Protein (OB), B219, LEP, OBS)

Polyclonal Antibody

Prod. No.:	L155
Host:	Goat
Pkg. Size:	1 mg, 50 µg

Description

Specificity:

Goat Anti-Rat Leptin recognizes Rat Leptin. This antigen affinity purified polyclonal antibody was purified using immobilized antigen agarose chromotography.

Background:

Leptin is a neuroendocrine hormone secreted from adipose tissue that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin is one of the most important adipose derived hormones.¹ It interacts with six types of receptors and once it binds to OB-Receptor it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in gene expression. One of the main effects on gene expression is the down-regulation of the expression of endocannabinoids.² High leptin levels are associated with psoriasis.³

Immunogen

Purified Recombinant Rat Leptin (>98%)

Formulation

This biotinylated antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.

Reconstitution

Aseptically reconstitute this biotinylated antigen affinity purified polyclonal antibody in sterile 1X PBS containing 0.1% BSA to a final concentration of 50 µg/ml.

Storage and Stability

This lyophilized biotinylated polyclonal antibody should be stored desiccated at -20°C. The reconstituted conjugate is stable for at least one month when stored at 2 - 8°C. For long term storage aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid More Than One Freeze Thaw Cycle.

Reported Applications

Each investigator should determine their own optimal working dilution for specific applications.

Country of Origin

USA

References

1. Mantzoros CS et al.(2006) Nat Clin Pract Endocrinol Metab. 2: 318
2. Hill RA. et al.(2002) Int. J. Obes. Relat. Metab. Disord. 26: 1407
3. Chen Y-J. et al.(2008) Arch Derm. 144: 1571

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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