Human PDGF-BB ELISA Development Kit
(Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF))
| Prod. No.: | P134 |
| Pkg. Size: | 15 plates, 45 plates |
Description
Background:
Platelet-derived growth factor-BB homodimers (PDGF-BB) activates all combinations of PDGF receptor subunits, whereas PDGF-AA acts specifically on PDGFR alpha.1 This constitutes a positive feed-back mechanism, which, for example, could serve to potentiate autocrine stimulation of growth.2 PDGF-BB plays an important role in the cellular metabolism of vascular wall by regulating the rate of macrophage-colony stimulating factor (M-CSF) production in vascular smooth muscle cells.3 PDGF-BB is also a potent wound-healing hormones that accelerate incisional repair.4 PDGF-BB is associated with excessive cell migration, proliferation and many growth-related diseases.5 It may be a new prognostic indicator for patients with colorectal cancer.6 PDGF-BB may also induce coronary atherosclerotic disease formation by stimulating coronary artery smooth muscle cell (CASMC) migration and proliferation through agent-specific regulation of oxidative status and utilization of different signal transduction pathways.5
References
1. Josef Pfeilschifter et al. (2005) Am Society of Nephrol. 10: 1681
2. Claesson-Welsh L. et al. (1991) J Biol Chem. 266: 21138
3. Yamada N et al. (1992) J Biol Chem. 267: 15455
4. Mustoe TA et al. (1991) J Lab Clin Med. 117: 373
5. Bayraktutan U. et al. (2008) J Mol Cell Cardiol. 45: 198
6. Mori M et al. (2008) Ann Surg Oncol. 15: 2129
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
