Recombinant Human TROP-2
Purified No Carrier Protein
(Tumor-Associated Calcium Signal Transducer 2 (TACSTD2), EGP-1, GA733, GA733-1, M1S1, T16, GP50)
| Prod. No.: | T404 |
| Source | NSO Cells |
| Pkg. Size: | 1 mg, 100 µg |
| Storage: | -20°C to -70°C Detailed storage instructions below. |
Description
Background:
Trop-2 is a cell surface glycoprotein1 that is highly expressed in a wide variety of epithelial cancers. There is little or no expression of Trop-2 in adult somatic tissue.2 Trop-2 is a novel calcium signal transducer3 involved in the regulation of cell- cell adhesion.4 It is an oncogene that has potential as a therapeutic target.2 It is a possible candidate gene for diagnosis and molecular target therapy of colorectal cancer.5
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human TROP-2 is Mr 49.2 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
State of Matter
Lyophilized
Purity
>95% by SDS Page and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Country of Origin
USA
References
1. Colnaghi MI. i>et al. (1992) Hybridoma 11: 539
2. Michel L et al. (2008) Mol Cancer Ther. 7: 280
3. Alberti S et al. (1998) Int J Cancer 75: 324
4. M. Piantelli et al. (2007) J Clin Oncol. 25: 10510
5. Masaki Mori et al. (2006) clin Cancer Res. 12: 3057
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
