Recombinant Human TROP-2
Purified No Carrier Protein
(Tumor-Associated Calcium Signal Transducer 2 (TACSTD2), EGP-1, GA733, GA733-1, M1S1, T16, GP50)
| Prod. No.: | T404 |
| Source | NSO Cells |
| Pkg. Size: | 1 mg, 100 µg |
| Storage: | -20°C to -70°C Detailed storage instructions below. |
Description
Background:
Trop-2 is a cell surface glycoprotein1 that is highly expressed in a wide variety of epithelial cancers. There is little or no expression of Trop-2 in adult somatic tissue.2 Trop-2 is a novel calcium signal transducer3 involved in the regulation of cell- cell adhesion.4 It is an oncogene that has potential as a therapeutic target.2 It is a possible candidate gene for diagnosis and molecular target therapy of colorectal cancer.5
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human TROP-2 is Mr 49.2 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
tlv rpsehalvdn dglydpdcdp egrfkarqcn qtsvcwcvns vgvrrtdkgd lslrcdelvr thhilidlrh rptagafnhs dldaelrrlf reryrlhpkf vaavhyeqpt iqielrqnts qkaagdvdig daayyferdi kgeslfqgrg gldlrvrgep lqvertliyy ldeippkfsm krltiegrmd pkscdkthtc ppcpapellg gpsvflfppk pkdtlmisrt pevtcvvvdv shedpevkfn wyvdgvevhn aktkpreeqy nstyrvvsvl tvlhqdwlng keykckvsnk alpapiekti skakgqprep qvytlppsrd eltknqvslt clvkgfypsd iavewesngq pennykttpp vldsdgsffl yskltvdksr wqqgnvfscs vmhealhnhy tqkslslspg khhhhhh
Country of Origin
USA
References
1. Colnaghi MI. i>et al. (1992) Hybridoma 11: 539
2. Michel L et al. (2008) Mol Cancer Ther. 7: 280
3. Alberti S et al. (1998) Int J Cancer 75: 324
4. M. Piantelli et al. (2007) J Clin Oncol. 25: 10510
5. Masaki Mori et al. (2006) clin Cancer Res. 12: 3057
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
