Anti-Mouse CD200 (Clone OX-90) – Purified in vivo PLATINUM™ Functional Grade

Anti-Mouse CD200 (Clone OX-90) – Purified in vivo PLATINUM™ Functional Grade

Product No.: C858

[product_table name="All Top" skus="C392"]

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Clone
OX-90
Target
CD200
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
OX-2
Isotype
IgG2a
Applications
FC
,
IHC
,
in vivo

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rat
Product Concentration
≥ 5.0 mg/ml
Endotoxin Level
<0.5 EU/mg as determined by the LAL method
Purity
≥98% monomer by analytical SEC
>95% by SDS Page
Formulation
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Product Preparation
Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Pathogen Testing
To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s Purified Functional PLATINUM<sup>TM</sup> antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Storage and Handling
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Additional Applications Reported In Literature ?
FC
IHC
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone OX-90 reacts with murine CD200 (OX-2).
Antigen Distribution
Thymocytes, neurons, B cells, splenic follicular dendritic cells and endothelium, and subsets of T cells and dendritic cells
Background
CD200 (OX-2) is an immune suppressor that regulates the of induction of cytokine production by conventional allostimulatory DC1,2. CD200 limits pro-inflammatory signals and has been shown to play an important role in cancer and immune disorders3,4.

Antigen Details

Research Area
Immunology

References & Citations

1. Gorczynski L, Chen Z, Hu J, et. al. J Immunol. Jan 15;162(2):774-81. 1999.
2. Koning N, Swaab DF, Hoek RM, Huitinga I. J Neuropathol Exp Neurol. Feb;68(2):159-67. 2009.
3. Stanley H. Appel, David R. Beers, Weihua Zhao. Neurobiology of Brain Disorders.
4. Liu JQ, Hu A, Zhu J, et. al. Adv Exp Med Biol. 1223:155-165. 2020.
Flow Cytometry
IHC
in vivo Protocol

Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.