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Anti-Mouse γ/δ T-Cell Receptor (TCR) Biotin

Monoclonal Antibody

Size


Prod. No.:T130
Clone:UC7-13D5
Isotype:Armenian Hamster IgG
Conc.:0.5 mg/ml
Pkg. Size:500 µg
Storage:2-8°C Detailed storage instructions below.
Description
Specificity:
The anti-mouse γ/δ T-cell receptor antibody reacts with all mouse TCR γ/δ heterodimers.

Antigen Distribution:
γδ TCR expression is observed on a subset of cells in the thymus, intestinal epithelium, skin, liver, peripheral lymphoid tissues, and peritoneum. The γδ TCR is involved in the antigen recognition of some bacterial or tumor-associated antigens presented by MHC class I.

Background:
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a heterodimer consisting of an α and β chain in 95% of T cells, while 5% of T cells have TCRs consisting of γ and δ chains. Engagement of the TCR with antigen and MHC results in activation of its T lymphocyte through a series of biochemical events mediated by associated enzymes, co-receptors and specialized accessory molecules.

Known Species Cross Reactivity: Ms+
Host Species
Armenian Hamster
Formulation
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Stability
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Reported Applications
FC
Each investigator should determine their own optimal working dilution for specific applications.


Country of Origin
USA
References
Bluestone, J. A. et al. (1991) Immunol. Rev. 120:5
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