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Anti-Mouse γ/δ T-Cell Receptor (TCR) DyLight® 755

Monoclonal Antibody


Prod. No.:T605
Clone:UC7-13D5
Isotype:Armenian Hamster IgG
Conc.:0.5 mg/ml
Pkg. Size:50 µg, 100 µg, 200 µg
Storage:2-8°C Detailed storage instructions below.
Description
Specificity:
The anti-mouse γ/δ T-cell receptor antibody reacts with all mouse TCR γ/δ heterodimers.

Antigen Distribution:
γδ TCR expression is observed on a subset of cells in the thymus, intestinal epithelium, skin, liver, peripheral lymphoid tissues, and peritoneum. The γδ TCR is involved in the antigen recognition of some bacterial or tumor-associated antigens presented by MHC class I.

Background:
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes (or T cells) that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a heterodimer consisting of an α and β chain in 95% of T cells, while 5% of T cells have TCRs consisting of γ and δ chains. Engagement of the TCR with antigen and MHC results in activation of its T lymphocyte through a series of biochemical events mediated by associated enzymes, co-receptors and specialized accessory molecules.

Reporter Molecule:
DyLight® 755 conjugated antibodies absorb light maximally around 754 nm (± 4 nm) and fluoresce maximally around 776 nm. DyLight® 750 has spectral properties that are very similar to other near-IR dyes, including Alexa Fluor 750, and has high solubility for maximal incorporation of the dye into the biomolecule of interest. DyLight® is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Known Species Cross Reactivity: Ms+
Host Species
Armenian Hamster
Formulation
This DyLight® 755 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Stability
This DyLight® 755 conjugate is stable when stored at 2-8°C. Do not freeze.
Reported Applications
FC
Each investigator should determine their own optimal working dilution for specific applications.


Country of Origin
USA
References
Bluestone, J. A. et al. (1991) Immunol. Rev. 120:5
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