Anti-Human Bonzo (NT-2)

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Bonzo recognizes an epitope near the N-terminus of Human Bonzo. This polyclonal antibody was purified using affinity chromatography.

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor (1-4). Bonzo/STRL33 serves as coreceptor for SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.

1. Deng, H. K. et al. (1997) Nature 388:296 2. Liao, F. et al. (1997) J. Exp. Med. 185:2015 3. Alkhatib, G. et al. (1997) Nature 388:238 4. Loetscher, M. et al. (1997) Curr. Biol. 7:652