Anti-Avian Influenza H5N1 NS2

Anti-Avian Influenza H5N1 NS2

Product No.: H1462

[product_table name="All Top" skus="H1462"]

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Target
H5N1 NS2
Product Type
Polyclonal Antibody
Alternate Names
Nonstructural Protein 2, Nuclear Export Protein, NEP
Applications
ELISA Indirect

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Product Size
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Antibody Details

Product Details

Reactive Species
Avian Influenza
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Avian Influenza H5N1 NS2 recognizes Avian Influenza H5N1 NS2. This polyclonal antibody was purified using affinity chromatography.
Background
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes, including the so-called “avian flu” or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by the influenza virus is the nonstructural protein (NS) 2. NS2 binds to the influenza matrix protein M1 that is bound to the ribonucleoprotein (RNP) complex and mediates the contact between the M1/RNP complex and the cellular exportin CRM, but does not interact with nucleosomes.

Antigen Details

PubMed
Research Area
Seasonal and Respiratory Infections

References & Citations

1. Thompson, W. W. et al. (2003) JAMA 289:179 2. Alexander, D. J. (2000) Vet. Microbiol. 74:3 3. Neumann, G. et al. (2000) EMBO J. 19:6751 4. Garcia-Robles, I. et al. (2005) Virology 332:329
Indirect Elisa Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.