GFRα-2 (Intermediate Domain) Blocking Peptide

15 amino acids near the center of human GFR-α2.

This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.

Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

15 amino acids near the center of human GFR-?2.

Glial cell line-derived neurotrophic factor family receptor alpha-2, also known as GFRA2, is the cognate co-receptor for the neurotrophic factor neurturin that is selectively expressed by isolectin B(4) (IB 4)-binding nociceptive sensory neurons.¹ GFRA2 is required for the development of the myenteric nerve plexus and is an excellent candidate gene for Hirschsprung disease (HSCR).² GFRalpha2 signaling is also needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.³

1. Lewin GR et al. (2002) J Physiol. 545: 43 2. Mulligan Lois M et al. (2001) Human Genetics 108: 409 3. Herzig KH et al. (2005) Diabetes 54: 1324