Recombinant Human Lymphotoxin βR

Recombinant Human Lymphotoxin βR

Product No.: L201

[product_table name="All Top" skus="L201"]

- -
- -
Alternate Names
Lymphotoxin Beta Receptor, CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRSF3
Product Type
Recombinant Protein
Expression Host
NS0 Cells
Species
Human
Applications
ELISA Cap

- -
- -
Product Size
- -
- -

Background

Lymphotoxin beta receptor (LTbR), a receptor for lymphotoxin, is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. LTbR pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proved beneficial in autoimmune diseases such as diabetes and rheumatoid arthritis.1

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
Immobilized Lymphotoxin βR has been used for affinity purification of Lymphotoxin α1/ß2 heterotrimers.
Fusion Protein Tag
Fc Fusion Protein
Protein Accession No.
NP_002333
Amino Acid Sequence
sqp qavppyasen qtcrdqekey yepqhriccs rcppgtyvsa kcsrirdtvc atcaensyne hwnylticql crpcdpvmgl eeiapctskr ktqcrcqpgm fcaawalect hcellsdcpp gteaelkdev gkgnnhcvpc kaghfqntss psarcqphtr cenqglveaa pgtaqsdttc knpleplppe msgtmlm & qavppyasen qtcrdqekey yepqhriccs rcppgtyvsa kcsrirdtvc atcaensyne hwnylticql crpcdpvmgl eeiapctskr ktqcrcqpgm fcaawalect hcellsdcpp gteaelkdev gkgnnhcvpc kaghfqntss psarcqphtr cenqglveaa pgtaqsdttc knpleplppe msgtmlmdie grmdpkscdk thtcppcpap ellggpsvfl fppkpkdtlm isrtpevtcv vvdvshedpe vkfnwyvdgv evhnaktkpr eeqynstyrv vsvltvlhqd wlngkeykck vsnkalpapi ektiskakgq prepqvytlp psrdeltknq vsltclvkgf ypsdiavewe sngqpennyk ttppvldsdg sfflyskltv dksrwqqgnv fscsvmheal hnhytqksls lspgkhhhhh h
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human Lymphotoxin βR is Mr 49.6 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 70 kDa.
Predicted Molecular Mass
49.6
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Bolstad, AI. et al. (2009) Arthritis Research & Therapy 11: R24
Elisa Sandwich Protocol
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
- -
- -
Prod No.
Description
L201
Products are for research use only. Not for use in diagnostic or therapeutic procedures.