Recombinant Human MSP

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like, is serum protein with homology to hepatocyte growth factor (HGF).¹ MSP is a soluble cytokine that belongs to the family of the plasminogen-related growth factors (PRGFs). PRGFs are alpha/beta heterodimers that bind to transmembrane tyrosine kinase receptors. Through binding to its receptor, MSP stimulates dissociation of epithelia and works as an inflammatory mediator by repressing the production of nitric oxide (NO).² MSP exerts proliferative and antiapoptotic effects, suggesting that it may play a role in tubular regeneration after acute kidney injury.³

AAA59872

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Gln19 predicted &amp

Lyophilized

This protein consists of a disulfide-linked heterodimer. The predicted molecular mass is 78.5 kDa (MSPα/β), 53.3 kDa (α chain), and 25.2 kDa (β chain). The actual molecular mass of Recombinant Human HGF is Mr 81 kDa, 62 kDa, and 30 kDa under reducing conditions.

This recombinant protein was lyophilized from a 0.2 μm filtered solution in sodium phosphate (NaH₂PO₄) and sodium chloride (NaCl).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Suda, T. et al. (1997) J Clin. Invest. 9: 701
2. Paolo, M. et al. (2001) Molecular Biol. Of Cell 12: 1341
3. Camussi, G. et al. (2008) J Am Soc Nephrol. 19: 1904