Recombinant Human TFF1

Trefoil factor 1, also known as TFF1 is a small cysteine-rich secreted protein that is frequently expressed in breast tumors.¹ It is also normally expressed in the stomach, and is found ectopically in gastrointestinal inflammatory disorders and in various carcinomas. It is involved in stomach ontogenesis and in the maintenance of the integrity of the mucosa, and may represent a pharmacological tool for prevention and healing of gastrointestinal ulcerations. TFF1 is a pleiotropic factor involved in mucin polymerization, cell motility, cell proliferation and/or differentiation, and possibly in the nervous system.²

Lyophilized

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

1. Westley BR et al. (2002) FASEB 2. Rio MC et al. (1998) Biochim Biophys Acta. 1378: F61