Recombinant Human CD86

CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.

Fc Fusion Protein

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Leu20

Lyophilized

The predicted molecular weight of Recombinant Human B7-2 is Mr 52.7 kDa. However, the actual molecular weight as observed by migration on SDS_PAGE is Mr 85-95 kDa.

52.7

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Celestin, J. et al. (2001) J. Immunol. 167:6097
2. Jellis, CL. et al. (1995) Immunogenetics 42:85
3. Short, JJ. et al. (2006) Virus Res. 122:144