Recombinant Human DR6

Death receptor-6 (DR6), also known as TNFRSF21, is a type I transmembrane protein and member of the death domain-containing TNFR superfamily. DR6 is expressed in most human tissues and the highest levels were detected in heart, brain, placenta, pancreas, thymus, lymph node and several non-lymphoid cancer cell lines. It functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses (1). DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-κB and JNK and cell apoptosis (2). In addition, DR6 is uniquely cleaved from the cell surface of tumor cell lines by MMP-14, which is associated with tumor malignancy. The ligand for DR6 has not been identified.

Fc Fusion Protein

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Gln42

Lyophilized

The predicted molecular weight of Recombinant Human DR6/TNFRSF21 is Mr 60.3 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 65-75 kDa.

60.3

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Na, S. et al.(2006)Immunol Lett. 106:42
2. Shi, J. et al. (2018) FEBS Open Bio. 8(9):1497-1507.