Recombinant Human TNFRSF14

Tumor necrosis factor receptor superfamily member 14 (herpesvirus entry mediator), also known as TNFRSF14, is the cellular receptor for TNF superfamily 14 (LIGHT).¹ TNFRSF14 is a type I membrane protein that is considered as a Herpesvirus entry mediator.² It is able to inhibit the proliferation, activation, and cytokine production of T cells. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.

The biological activity of Human HVEM-Fc was determined by its ability to inhibit apoptosis of mouse L-929 cells treated with 0.1 ng/ml of rhTNF-β. The expected ED₅₀ for this effect is typically 0.5 - 2 μg/ml.

Fc Fusion Protein

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Pro37

Lyophilized

The predicted molecular weight of Recombinant Human TNFRSF14 is Mr 45 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 60 kDa.

45

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Park, JE. et al. (2001) Arterioscler Thromb Vasc Biol. 21: 1873
2. Montgomery, RI et al. (1996) Cell 87: 427