Recombinant Mouse IL-17F

Recombinant Mouse IL-17F

Product No.: I-531

[product_table name="All Top" skus="I-531"]

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Alternate Names
Interleukin-17F, C87042, Il17f
Product Type
Recombinant Protein
Expression Host
E. coli Cells
Species
Mouse

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Product Size
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Background

IL-17F, also known as C87042, is a homodimeric protein that is a member of the IL-17 family of cytokines produced by activated T cells and monocytes (1). IL-17F can stimulate production of other cytokines such as IL-6, IL-8 and G-CSF as well as regulate cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (2). It is an important regulator of inflammatory responses that functions differently than IL-17 in immune responses and diseases (3). IL-17F inhibits the angiogenesis of endothelial cells and induces endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1 (4). Skin biopsy samples from psoriasis patients show the upregulation of IL-17F expression (5).

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Protein Accession No.
Amino Acid Sequence
mailrevaar knpkagvpal qkagncpple dntvrvdiri fnqnqgisvp refqnrsssp wdynitrdph rfpseiaeaq crhsgcinaq gqedstmnsv aiqqeilvlr repqgcsnsf rlekmllkvg ctcv
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-17F is Mr 15 kDa.
Predicted Molecular Mass
15
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Starnes, T. et al. (2001) J. Immonol. 167:4137
2. Starovasnik, MA. et al. (2001) Embo. J. 20:5332
3. Dong, C. et al. (2008) J. Exp. Med. 205:1063
4. Starnes, T. et al. (2001) J. Immunol. 167:4137
5. Watanabe, H. et al. (2009) J. Invest. Dermatol. 129:650
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.