Recombinant Human IL-3 Rα

Recombinant Human IL-3 Rα

Product No.: I-559

[product_table name="All Top" skus="I-559"]

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Alternate Names
Interleukin-3 Receptor Alpha, RP11-261P4.2, CD123, IL3R, IL3RAY, IL3RX, IL3RY, MGC34174, hIL-3Ra
Product Type
Recombinant Protein
Expression Host
NS0 Cells
Species
Human

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Product Size
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Background

Interleukin 3 receptor alpha (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a type I transmembrane protein that is expressed on the large majority of progenitor cells. IL-3R alpha function can be defined by the activity of its ligand interleukin-3. IL-3 is a multipotent cytokine that promotes the development of hemopoietic progenitors into cells of the erythroid, myeloid and lymphoid lineages.1 CD123 may be a promising strategy for the preferential ablation of acute myelogenous leukemia (AML) cells.2

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Protein Accession No.
Amino Acid Sequence
k edpnppitnl rmkakaqqlt wdlnrnvtdi ecvkdadysm pavnnsycqf gaislcevtn ytvrvanppf stwilfpens gkpwagaenl tcwihdvdfl scswavgpga padvqydlyl nvanrrqqye clhyktdaqg trigcrfddi srlssgsqss hilvrgrsaa fgipctdkfv vfsqieiltp pnmtakcnkt hsfmhwkmrs hfnrkfryel qiqkrmqpvi teqvrdrtsf qllnpgtytv qirarervye flsawstpqr fecdqeegan trawr
N-terminal Sequence Analysis
Lys20
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-3 Rα is Mr 33 kDa.
Predicted Molecular Mass
33
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Garnache-Ottou, F. et al. (2015) Haematologica. 100(2):223-30
2. Phillips, GL. et al. (2000) Leukemia 14: 1777
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.