Recombinant Mouse IL-2

Recombinant Mouse IL-2

Product No.: I-837

[product_table name="All Top" skus="I-837"]

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Alternate Names
Interleukin-2, T-cell growth factor (TCGF)
Product Type
Recombinant Protein
Expression Host
E. coli Cells
Species
Mouse
Applications
ELISA Cap
FC

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Product Size
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Background

IL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease.

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Protein Accession No.
Amino Acid Sequence
aptssstsss taeaqqqqqq qqqqqqhleq llmdlqells rmenyrnlkl prmltfkfyl pkqatelkdl qcledelgpl rhvldltqsk sfqledaenf isnirvtvvk lkgsdntfec qfddesatvv dflrrwiafc qsiistspq
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-2 (Cys160Ser) is Mr 17 kDa.
Predicted Molecular Mass
17
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from a sterile solution containing 10 mM sodium acetate (NaOAc), pH 6.0.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Schachter, J. et al. (2009) Cytotherapy 11: 206
2. Sodora, DL. et al. (2009) Curr HIV Res. 7: 83
3. Alcocer-Varela, J. et al. (2009) Autoimmun Rev. 9(1):34-9.
Elisa Sandwich Protocol
Flow Cytometry
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.