Recombinant Human Relaxin-3

Relaxin-3 (RNL3) is one of the 7 peptides of Relaxin which is an insulin-related peptide hormone.¹ Relaxin 3 is expressed in neurons of the brain stem that inneravate wide areas of the forebrain. Relaxin 3 mRNA levels in these neurons are increased in response to restraint stress, and by central administration of corticotropin-releasing factor (CRF).² Relaxin-3 may act as a central signal linking nutritional status and reproductive function.³

dvlaglsssc ckwgcsksei sslc (A chain) & aapygvrlcg refiravift cggsrwr (B chain)

Asp119 (A chain) & Ala27 (B chain)

Lyophilized

This protein consists of a disulfide-linked heterodimer. The predicted molecular weight of Recombinant Human Relaxin-3 is Mr A Chain-2.46, B Chain-3.04 kDa.

A Chain-2.46, B Chain-3.04

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Kane, JF. et al. (2008) Protein Expr Purif. 60: 110
2. Yoshimoto, K. et al. (2009) J Neurosci Res. 87: 820
3. Bloom, SR. et al. (2008) Am J Physiol Endocrinol Metab 295: E278