Anti-Human CD105 – FITC
Anti-Human CD105 – FITC
Product No.: C774
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Clone 8E11 Target CD105 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Endoglin, Ancillary TGF-beta Receptor Isotype IgM Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen PMA-induced U-937 cells. U-937 is an human lymphoma cell line that expresses markers and properties of monocytes. Formulation This conjugate is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative. Storage and Handling Store at 2-8°C protected from light. DO NOT FREEZE. For long term storage aliquot conjugate into working volumes and store at 2-8°C for up to a year. Country of Origin USA Shipping Next Day Ambient Excitation Laser Blue Laser (488 nm) RRIDAB_2829847 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this 8E11 antibody for staining cells in flow cytometry is ≤ 1 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application. Additional Reported Applications For Relevant Conjugates ? IHC (Frozen) IP For specific conjugates of this clone, review literature for suggested application details. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Anti-Human CD105 (Clone 8E11) recognizes Human CD105. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Endoglin is an endothelial homodimeric membrane antigen containing the tripeptide sequence RGD, which is a recognition motif for adhesion receptors of the integrin family. It has been proposed that endoglin is a TGF-beta receptor. Endoglin is a glycoprotein present on endothelial cells of capillaries, arterioles and venules in a variety of tissues and at low levels on acute lymphoblastic and myelocytic leukemia cells. Antigen DetailsLigand/Receptor TGF-ß1, TGF-ß3 PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Lastres, P. et. al. (1994) Biochem. J. 301:765
2. Westenend, P. J. et al. (1994) J. Am. Soc. Neph. 5:822
3. Fernandez-Ruiz, E. et al. (1993) Cell Genet. 64:204
4. Bellon, T. et al. (1993) Eur. J. Immunol. 23:2340
5. Lastres, P. et al. (1992) Eur. J. Immunol. 22:393
6. O'Connell, P. J. et al. (1992) Clin. Exp. Immunol. 90:154
7. Lopez-Casillas, F. et al. (1991) Cell 67:785 Technical Protocols |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.