Antibody DetailsProduct DetailsReactivity Species Human Host Species Mouse Product Concentration 0.1 mg/ml RRIDAB_2829731 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone GRM1 recognizes human CD16. Antigen Distribution CD16 is expressed on NK cells, activated monocytes, macrophages, neutrophils, and placental trophoblasts. Background CD16 is expressed in two forms: CD16a and CD16b. CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (FcγRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (FcγRIII) and CD16 (FcγRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses. Antigen DetailsProtein Ligand/Receptor Aggregated IgG, IgG-antigen complex PubMed NCBI Gene Bank ID UniProt.org Technical Protocols   |
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