Anti-Human CD16 – Purified

Pricing & Details

Product No.C465
Clone
GRM1
Protein
CD16
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
FcγRIII
Isotype
Mouse
IgG2a
Applications
FC
,
IP
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C465-0.1 mg
0.1 mg
$310.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Product Concentration
0.1 mg/ml
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone GRM1 recognizes human CD16.
Antigen Distribution
CD16 is expressed on NK cells, activated monocytes, macrophages, neutrophils, and placental trophoblasts.
Background
CD16 is expressed in two forms: CD16a and CD16b. CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (FcγRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (FcγRIII) and CD16 (FcγRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses.

Antigen Details

Protein
Ligand/Receptor
Aggregated IgG, IgG-antigen complex
PubMed
NCBI Gene Bank ID
Flow Cytometry
Immunoprecipitation Protocol
General Western Blot Protocol

Formats Available

Prod No.
Description
C465
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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