Anti-Human CD19 (Clone HD37) – Purified
Anti-Human CD19 (Clone HD37) – Purified
Product No.: C572
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Clone HD37 Target CD19 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Pan B-Cells, B-lymphocyte Surface Antigen B4 Isotype IgG1 Applications FC , IP |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Product Concentration 0.1 mg/ml Formulation This purified monoclonal antibody is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative. Storage and Handling For use within 1 month of purchase store at 2-8°C. For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2829770 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone HD37 recognizes human CD19. Antigen Distribution CD19 is expressed in the majority of Pro-B cells to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19. Background CD19 is a 95 kD transmembrane glycoprotein and member of the Ig superfamily. The antigen serves as an adaptor protein; drawing cytoplasmic signaling proteins to the membrane. It works via the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Because of its presence on all B cells, CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for the immunotherapy of lymphoproliferative disorders. Emerging studies indicate that CD19 plays an active role in fueling the growth of these cancers, most notably by stabilizing the concentrations of the MYC oncoprotein, making CD19 an attractive therapeutic target with respect to its downstream signaling. Antigen DetailsLigand/Receptor Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Leukocyte Typing V (1995) Oxford University Press
2. Leukocyte Typing IV (1989) Oxford University Press
3. Leukocyte Typing III (1987) Oxford University Press
4. Leukocyte Typing II Oxford University Press Technical Protocols |
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Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.