Anti-Human CD49f (Integrin α6) (Clone 4F10) – Purified
Anti-Human CD49f (Integrin α6) (Clone 4F10) – Purified
Product No.: C627
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Clone 4F10 Target CD49f Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Integrin α6 Isotype IgG2b Applications FC , IP |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Cell Line SW/222 (Human Colorectal Carcinoma) Product Concentration 0.1 mg/ml Formulation This purified monoclonal antibody is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative. Storage and Handling For use within 1 month of purchase store at 2-8°C. For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2829785 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Anti-Human CD49f (Clone 4F10) recognizes Human CD49f. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody is specific to the integrin alpha6 chain which is expressed on epithelial and endothelial basement membrane. The VLA alpha6 chain, which consists of a single disulphide linked 120 kDa subunit and a small doublet subunit of 25/30 kDa, is non-covalently associated with the VLA beta-chain (CD29) in VLA-6 or alpha6/beta1 complex or with integrin beta4 chain (alpha6/beta4) The antigen is also expressed on platelets, monocytes, thymocytes and T-lymphocytes. Antigen DetailsLigand/Receptor With integrin β1 (CD29) forms VLA-6, with integrin β4 (CD104) forms a6β4 integrin; laminin and kalinin are ligands for these receptors PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Ramaswamy, A. et al. (1995) J. Path. 176(3):227
2. Dobson, H. et al. (1994) GUT 35:1343
3. Pignatelli, M. et al. (1992) Human Pathol. 23:1159 Technical Protocols |
Formats Available
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.