Anti-Human CD61 (Integrin β3) (Clone PM6/13) – PE

Human Platelet Plasma Membrane

This conjugate is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative.

Store at 2-8°C protected from light. DO NOT FREEZE. For long term storage aliquot conjugate into working volumes and store at 2-8°C for up to a year.

Next Day 2-8°C

Blue Laser (488 nm) and/or Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Mouse Anti-Human CD61 (Clone PM6/13) recognizes Human CD61. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. The antibody is specific for the 110 kDa platelet glycoprotein GP IIIa and inhibits platelet aggregation and activation induced by thrombin and collagen. The platelet glycoprotein is the integrin beta3 chain of the vitronectin receptor and GPIIb/IIIa. The antigen is present on platelets and megakaryocytes.

Platelets: >98%
Megakaryocytes: >98%
Granulocytes: 0%
Monocytes: 0%
LGL cells: 0%
B cells: 0%
T cells: 0%
Peripheral blood lymphocytes: 0%

Anti-CD61 may be used to identify platelets and megakaryocytes. It may also be used in studies to characterize leukemias and in research of cell adhesion molecules.

Fibronectin, vitronectin, vWF

1. Tsopanoglou, N. E. et al. (2002) Am. J. Physiol. Cell Physiol. 283:C1501 2. Boettiger, D et al. (2001) Mole. Biol. of the Cell 12(5): 1227