Anti-Human CD62E (E-Selectin) – PE

Pricing & Details

Product No.C676
Clone
1.2B6
Protein
CD62E
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
E-Selectin, ELAM-1, SELE, ELAM, ESEL, LECAM2
Isotype
Mouse
IgG1
Applications
FC
Prod No.
Size
Price
Avail.
Qty
Add to cart
C676-100 tests
100 tests
$405.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
TNF-Activated Human Umbilical Vein Endothelial Cells
Formulation
This conjugate is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative.
Storage and Handling
Store at 2-8°C protected from light. DO NOT FREEZE. For long term storage aliquot conjugate into working volumes and store at 2-8°C for up to a year.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Blue Laser (488 nm) and/or Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human CD62E (Clone 1.2B6) recognizes Human CD62E. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. The antibody is specific to the human antigen E-selectin (ELAM-1, 115 kDa) that is expressed on activated endothelial cells. The ligand is expressed on neutrophils and may function as an early part in neutrophil binding to the endothelium.
Background
CD62E, also known as E-Selectin, is a type I membrane glycoprotein that belongs to the selectin family of surface molecules which is activated by cytokines and mediates the binding of leukocytes. Like other selectins, it plays an important part in inflammation. During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury.

Antigen Details

Protein
Ligand/Receptor
Siayl Lewis X (CD15s) and PSGL-1 (CD162) bind to CD62E. Recently, CLA (cutaneous lymphocyte antigen) has also been reported in interact with CD62E
PubMed
NCBI Gene Bank ID

References & Citations

1. Leukocyte Typing Workshop VI (1996) Oxford University Press 2. Leukocyte Typing Workshop V (1995) Oxford University Press 3. Bevilacqua, M. P. et al. (1993) J. Clin. Invest. 91:379 4. Groves, R. W. et al. (1991) Br. J. Dermatol. 124:117 5. Wellicome, S. M. et al. (1990) J. Immunol. 144:2558
Flow Cytometry

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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