Anti-Human CD90 (Thy-1) – FITC

Pricing & Details

Product No.C750
Clone
F15-42-1
Protein
CD90
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Thy-1, CD90, CDw90
Isotype
Mouse
IgG1
Applications
FC
Prod No.
Size
Price
Avail.
Qty
Add to cart
C750-100 tests
100 tests
$400.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Formulation
This conjugate is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative.
Storage and Handling
Store at 2-8°C protected from light. DO NOT FREEZE. For long term storage aliquot conjugate into working volumes and store at 2-8°C for up to a year.
Country of Origin
USA
Shipping
Next Day Ambient
Excitation Laser
Blue Laser (488 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone F15-42-1 recognizes human CD90.
Antigen Distribution
CD90 is expressed by thymocytes, peripheral T cells, myoblasts, epidermal cells, and keratinocytes.
Background
CD90 is a 28-30 kD GPI-linked membrane glycoprotein and is part of the Ig superfamily. It interacts with CD45 in signal transduction. CD90 mediates adhesion of thymocytes to thymic stroma. It has been reported that CD90 binds with β2 and β3 integrins and is involved in the inhibition of hematopoietic stem cells proliferation and differentiation, as well as the regulation of cell adhesion and neurite outgrowth. It can be used as a marker for various stem cells, such as hematopoietic stem cells, and for the axonal processes of mature neurons. For use in FACS, CD90 is a popular surface marker for stem cells in combination with other markers such as CD34. There are two alleles for CD90 in mice that differ by one amino acid. The difference being that CD90.1 (Thy1.1) has an arginine and CD90.2 (Thy1.2) has a glutamine at position 108. CD90.2 is more prevalent and is expressed in most mice strains. CD90.1 is only expressed by a select few mice strains including AKR/J and PL strains. CD90.2 is a 25-35 kD GPI-anchored membrane glycoprotein. Like CD90, it is also in the Ig superfamily, interacts with CD45, and has involvement in signal transduction. The function of CD90.2 is thought to play roles in cognition, axon growth, T lymphocyte function, and apoptosis. CD90 acts as tumor suppressor for some tumors due to its action in upregulating thrombospondin, SPARC (osteonectin), and fibronectin. On the other hand, it has been suspected to aid in the spread of circulating melanoma cells. Regarding prostate cancer, CD90 has therapeutic potential for specific drug targeting due to its expression in cancer associated stroma, but not in normal stroma.

Antigen Details

Protein
Ligand/Receptor
β3 integrin, β2 integrin
PubMed
NCBI Gene Bank ID

References & Citations

1. Clayton, A. et al. (1997) J. Am. Soc. Nephrol. 8:604 2. Delchau, R. et al. (1989) Immunol. Neurol. & Therap. Appl. Eds. Reif & Schlesinger, p. 185 3. McKenzie, J. L. et al. (1981) Brain Res. 230:307
Flow Cytometry

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.