Anti-Human β-Defensin-1 (BD-1)-Biotin

Pricing & Details

Product No.B425
Protein
β-Defensin-1
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
WB
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Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
Purified Recombinant Human BD-1 (>98%)
Formulation
This biotinylated antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.
Storage and Handling
This lyophilized biotinylated polyclonal antibody should be stored desiccated at -20°C. The reconstituted conjugate is stable for at least one month when stored at 2 - 8°C. For long term storage aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid More Than One Freeze Thaw Cycle.
Country of Origin
USA
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Beta-Defensin-1 (BD-1) recognizes Human Beta-Defensin-1. This antigen affinity purified polyclonal antibody was purified using immobilized antigen agarose chromotography.
Background
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.

Antigen Details

General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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