Anti-Human CD62E (E-Selectin) – FITC

Anti-Human CD62E (E-Selectin) – FITC

Product No.: C675

[product_table name="All Top" skus="C675"]

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Clone
1.2B6
Target
CD62E
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
SELE, CD62E, Endothelial Leukocyte Adhesion Molecule (ELAM), ELAM1, ESEL, LECAM2
Isotype
IgG1
Applications
FC

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
TNF-Activated Human Umbilical Vein Endothelial Cells
Formulation
This conjugate is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative.
Storage and Handling
Store at 2-8°C protected from light. DO NOT FREEZE. For long term storage aliquot conjugate into working volumes and store at 2-8°C for up to a year.
Country of Origin
USA
Shipping
Next Day Ambient
Excitation Laser
Blue Laser (488 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human E-Selectin (Clone 1.2B6) recognizes an epitope on Human E-Selectin. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
E-selectin, also known as CD62E is an inducible leukocyte adhesion glycoprotein specifically expressed by endothelial cells.1 E-selectin helps initiate recruitment of circulating leukocytes to cutaneous, bone and inflamed tissues.2 E-selectin is found in inflammatory skin lesions in psoriasis, contact dermatitis, and delayed- type hypersensitivity, in arthritic joints, and in heart and renal allografts undergoing rejection.3 E-selectin-targeting antibody drug conjugate has potential as a prostate cancer therapy.4

Antigen Details

Ligand/Receptor
Siayl Lewis X (CD15s) and PSGL-1 (CD162) bind to CD62E. Recently, CLA (cutaneous lymphocyte antigen) has also been reported in interact with CD62E
PubMed
NCBI Gene Bank ID

References & Citations

1. Milstone D et al. (2004) PNAS 101: 8005 2. Dimitroff CJ et al. (2009) J Visualized Experiments 3. Takako Hirata et al. (2005) J Immunol. 175: 8042 4. Ramakrishnan Vanitha et al. (2003) Cancer Res. 63: 6387
Flow Cytometry
Products are for research use only. Not for use in diagnostic or therapeutic procedures.