Anti-Human CD62E (E-Selectin) – Purified

TNF-Activated Human Umbilical Vein Endothelial Cells

This purified monoclonal antibody is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative.

For use within 1 month of purchase store at 2-8°C. For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Mouse Anti-Human E-Selectin (Clone 1.2B6) recognizes an epitope on Human E-Selectin. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

E-selectin, also known as CD62E is an inducible leukocyte adhesion glycoprotein specifically expressed by endothelial cells.¹ E-selectin helps initiate recruitment of circulating leukocytes to cutaneous, bone and inflamed tissues.² E-selectin is found in inflammatory skin lesions in psoriasis, contact dermatitis, and delayed- type hypersensitivity, in arthritic joints, and in heart and renal allografts undergoing rejection.³ E-selectin-targeting antibody drug conjugate has potential as a prostate cancer therapy.⁴

Siayl Lewis X (CD15s) and PSGL-1 (CD162) bind to CD62E. Recently, CLA (cutaneous lymphocyte antigen) has also been reported in interact with CD62E

1. Milstone D et al. (2004) PNAS 101: 8005 2. Dimitroff CJ et al. (2009) J Visualized Experiments 3. Takako Hirata et al. (2005) J Immunol. 175: 8042 4. Ramakrishnan Vanitha et al. (2003) Cancer Res. 63: 6387