Anti-Human CD62E (E-Selectin) – Purified

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Pricing & Details

Product No.C674
Clone
1.2B6
Protein
CD62E
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
SELE, CD62E, Endothelial Leukocyte Adhesion Molecule (ELAM), ELAM1, ESEL, LECAM2
Isotype
Mouse
IgG1
Applications
FC
,
IP
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C674-0.1 mg
0.1 mg
$420.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
TNF-Activated Human Umbilical Vein Endothelial Cells
Product Concentration
0.1 mg/ml
Formulation
This purified monoclonal antibody is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative.
Storage and Handling
For use within 1 month of purchase store at 2-8°C. For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human E-Selectin (Clone 1.2B6) recognizes an epitope on Human E-Selectin. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
E-selectin, also known as CD62E is an inducible leukocyte adhesion glycoprotein specifically expressed by endothelial cells.1 E-selectin helps initiate recruitment of circulating leukocytes to cutaneous, bone and inflamed tissues.2 E-selectin is found in inflammatory skin lesions in psoriasis, contact dermatitis, and delayed- type hypersensitivity, in arthritic joints, and in heart and renal allografts undergoing rejection.3 E-selectin-targeting antibody drug conjugate has potential as a prostate cancer therapy.4

Antigen Details

Protein
Ligand/Receptor
Siayl Lewis X (CD15s) and PSGL-1 (CD162) bind to CD62E. Recently, CLA (cutaneous lymphocyte antigen) has also been reported in interact with CD62E
PubMed
NCBI Gene Bank ID

References & Citations

1. Milstone D et al. (2004) PNAS 101: 8005 2. Dimitroff CJ et al. (2009) J Visualized Experiments 3. Takako Hirata et al. (2005) J Immunol. 175: 8042 4. Ramakrishnan Vanitha et al. (2003) Cancer Res. 63: 6387
Flow Cytometry
Immunoprecipitation Protocol
General Western Blot Protocol

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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