Purified Recombinant Rat Leptin (>98%)
This biotinylated antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.
Storage and Handling
This lyophilized biotinylated polyclonal antibody should be stored desiccated at -20°C. The reconstituted conjugate is stable for at least one month when stored at 2 - 8°C. For long term storage aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid More Than One Freeze Thaw Cycle.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Goat Anti-Rat Leptin recognizes Rat Leptin. This antigen affinity purified polyclonal antibody was purified using immobilized antigen agarose chromotography.
Leptin is a neuroendocrine hormone secreted from adipose tissue that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin is one of the most important adipose derived hormones.1 It interacts with six types of receptors and once it binds to OB-Receptor it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in gene expression. One of the main effects on gene expression is the down-regulation of the expression of endocannabinoids.2 High leptin levels are associated with psoriasis.3
References & Citations
1. Mantzoros CS et al.(2006) Nat Clin Pract Endocrinol Metab. 2: 318 2. Hill RA. et al.(2002) Int. J. Obes. Relat. Metab. Disord. 26: 1407 3. Chen Y-J. et al.(2008) Arch Derm. 144: 1571
Products are for research use only. Not for use in diagnostic or therapeutic procedures.