Anti-Rat SCF – Biotin
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Antibody DetailsProduct DetailsReactive Species Rat Host Species Goat Immunogen Purified Recombinant Rat SCF (>98%) Formulation This biotinylated antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added. Storage and Handling This lyophilized biotinylated polyclonal antibody should be stored desiccated at -20°C. The reconstituted conjugate is stable for at least one month when stored at 2 - 8°C. For long term storage aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid More Than One Freeze Thaw Cycle. Country of Origin USA RRIDAB_2831766 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Goat Anti-Rat Stem Cell Factor (SCF) recognizes Rat Stem Cell Factor. This antigen affinity purified polyclonal antibody was purified using immobilized antigen agarose chromotography. Background Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor1 is a paracrine regulator of germ cell development.2 SCF has the ability to stimulate the growth of hematopoietic progenitor cells and to generate colony-forming cells (CFC) from highly enriched populations of hematopoietic cells.3 SCF is produced by the Sertoli cells and involved in the local regulation of spermatogenesis4 and liver regeneration.5 SCF in conjunction with interleukin-31 may play a significant role in airway remodeling by promoting the recruitment of bone marrow-derived fibroblast precursors into the lung with the capacity to promote lung myofibroblast differentiation.6 Antigen DetailsPubMed References & Citations1. Toppari, J. et al. (1999) Endocrin 140: 1492 2. Adamson, JW. et al. (1991) PNAS 88: 7420 3. Hervé, L. et al. (2005) J of Endocrin. 186: 131 4. Ramadori, G. et al. (2009) Lab Invest. 89(5):562-74. 6. Phan, SH. et al. (2009) AM J Pathol. 174: 390 Technical Protocols |
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